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Valenzuela Medical Center, initially known as Valenzuela Emergency Hospital, was established through a local council in 1979 as a 25-bed secondary hospital under LGU supervision and funding.  The hospital was originally housed in a renovated municipal hall in Polo, Valenzuela.   In 1983 the operation of the hospital was transferred to the Department of Health – Region 3 and It was nationalized on January 1985 directly under Region III through PD 811 and it was later renamed  as Valenzuela District Hospital. 

In 1987, through EO 119, it was absorbed by the newly created DOH-NCR under District Health Office No. I.   In 1992, through RA 7218, it was upgraded into a 100-bed  secondary hospital and later renamed as Valenzuela General Hospital.   In 1998, with the release of additional plantilla of  employees including medical staff, Valenzuela General Hospital became departmentalized into 4 basic medical departments namely: Obstetrics-Gynecology, Surgery, Medicine and Pediatrics. 

Eventually on May 1, 1999, the hospital transferred to its present site in Karuhatan, Valenzuela City.    It is a four storey concrete building in a 1800 sq. meter of land.   It was licensed as a 100 bed Tertiary-Teaching and Training hospital. In 2005 Valenzuela General Hospital was licensed as tertiary level 4 hospital by the Department of Health and accredited by Philhealth as tertiary – 100 beds hospital. In 2007 Under Republic Act No. 9421 Valenzuela General Hospital was upgraded to 200 bed Tertiary – Teaching and Training hospital and it was renamed as Valenzuela Medical Center and in 2011 under DOH Administrative Order No. 2011-0007 the Implementing Rules and Regulations of RA 9421 was approved.